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Revitalize your Health

Revitalize your HealthRevitalize your HealthRevitalize your Health

Harnessing the regenerative powers of immune-tolerated stem cells with innovative technology through MBTC-MSC-EXO™.



Learn More About Stem Cells and Exosomes

Revitalize your Health

Revitalize your HealthRevitalize your HealthRevitalize your Health

Harnessing the regenerative powers of immune-tolerated stem cells with innovative technology through MBTC-MSC-EXO™.



Learn More About Stem Cells and Exosomes

Experience the Korean Regeneration Technology

Technological Advantages of MBTC-MSC-EXO™

Immune Tolerated Stem Cell Technology MBTC-MSC-EXO™


The team has been working on harnessing the regenerative powers of stem cells by working on an innovative cultivation technique and unique stem cell line that would be regenerative and immune-tolerated. Thus came the development of MBTC-MSC-EXO™.

 

MBTC-MSC-EXO™ refers to the exosomes and ectosomes secreted by the patented stem cell line of mesenchymal stem cells. Here are some advantages of this technology as an investigational therapy:


1. Cell-free therapy

  • Stem cell culture media does not include cells, all cells (live and dead cells as well as cell debris) are filtered out of the culture media using MCE MF-Millipore™). Use of cells directly in a human body is often associated with immune reactions due to the presence of a foreign cell body with different DNA.

2. Patented Fetal Bovine Serum (FBS)-Free Technology

  • The current technology described in the patent does not entail the use of FBS, but rather a medium mainly consisting of over 30 plant extracts (SigGROW™).
  • FBS is one of the industry-standard culture growth mediums. However, use of FBS is also associated with immune response and rejection due to the presence of bovine animal proteins and nucleic acids. 

3. Immune tolerance

  • Perhaps most significantly, the current technology enables the stem cells to continuously secrete and express Human Leukocyte Antigen-G gene (HLA-G) proteins. HLA-G plays a crucial role during pregnancy, where it is expressed on the fetal cells to evade maternal immune responses and ensure successful pregnancy. 
  • HLA-G exerts immunomodulatory effects. It inhibits the activation and function of various immune cells, including cytotoxic T cells, natural killer cells, and antigen-presenting cells. 
  • This suppression helps establish immune tolerance, prevents rejection of the fetus during pregnancy, and maintains immune homeostasis in certain pathological conditions. 

4. Mass Production of Proteins and Extracellular Vesicles

  • A separate patented technology describes the unique way that this research team has developed for producing an outstanding amount and variety of different proteins, cytokines, and growth factors within the stem cell culture medium.

5. Filtered and Tested

  • There is no contamination with microorganisms and viruses in the stem cell culture media. 
  • The medium is cultured in a sterile environment, filtered (through MCE MF-Millipore™) and adventitious virus test and microbial residual tests are both performed in accordance with approved criteria in the ministry of Food and Drug Safety. 

Our Patents

The team's work has resulted in the approval of multiple patents spanning US, Korea, and Japan.

View Our Patents

ostteoarthritis in Animal models

In the image shown above, we can see the joints of the mice with osteoarthritis. The white coating is the cartilage of the mouse, which in healthy rats should be evenly spread in a layer. The mice were treated with the following:

  1. Control: No treatment
  2. Mesenchymal Stem Cells (MSCs)
  3. Immune Tolerized Mesenchymal Stem Cell Extracellular Vesicles (itMSC-EVs; also known as MBTC-MSC-EXO™)

From this image, one can compare the results of the various interventions. Mice treated with MBTC-MSC-EXO™ saw regenerated cartilage that was spread across evenly, thus demonstrating the restorative capabilities of MBTC-MSC-EXO™.

Visualizing Real Changes

    Testimonials

    Our medical professionals are committed to providing excellence in care to ensure you receive the best possible outcome. See what others have said about this therapy.

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